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Year : 2014  |  Volume : 16  |  Issue : 2  |  Page : 106-109

HAART (Highly Active Anti-Retroviral Therapy) : An overview


1 Resident Medicine, INHS Asvini, Colaba, Mumbai - 4000 05, India
2 Senior Advisor Medicine & Gastroentrology, INHS Asvini, Colaba, Mumbai - 4000 05, India

Correspondence Address:
Praful Pande
Resident Medicine, INHS Asvini, Colaba, Mumbai - 4000 05
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-3605.203369

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Highly Active Anti - Retroviral Therapy (HAART) is a triple combination of ART drugs and is a n effective tool to control disease progression in HIV disease. HAART is not started in all patients of HIV and indication to start HAART depends on clinical symptoms, CD4 cell count, HIV viral load. Advantages of HAART includes suppression of viremia and virus shedding in semen and vaginal secretions , increased CD4 + T cell count, reduced immune activation, restoration of lymph node architecture, clinical improvement, prolonged survival, fewer opportunistic infections and HIV - associated malignancies. Problem with therapy are pill burden, non-availability of drugs, food and storage restrictions, drug-drug interactions, severe side-effects, reduction in quality of life measures, emergence of multiple drug resistance mutations.


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