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 Table of Contents  
LETTER TO EDITOR
Year : 2017  |  Volume : 19  |  Issue : 1  |  Page : 72-73

Interim results of a study of the effect of hyperbaric oxygen therapy on healing of chronic leg ulcers


1 DNB General Surgery Resident, Kokilaben Dhirubhai Ambani Hospital, Mumbai, India
2 Consultant Vascular Surgeon, Kokilaben Dhirubhai Ambani Hospital, Mumbai, India
3 Consultant Physiatrist, Kokilaben Dhirubhai Ambani Hospital, Mumbai, India

Date of Web Publication17-Aug-2017

Correspondence Address:
Dr Jessica Shah
DNB General Surgery Resident, Kokilaben Dhirubhai Ambani Hospital, Mumbai
India
Dr Praveen Kumar Krosuri
Department of General Surgery, Kokilaben Dhirubahi Ambani Hospital, Four Bungalows, Andheri West, Mumbai, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmms.jmms_8_17

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How to cite this article:
Krosuri PK, Sekhar R, Srivastava A, Attar A, Shah J. Interim results of a study of the effect of hyperbaric oxygen therapy on healing of chronic leg ulcers. J Mar Med Soc 2017;19:72-3

How to cite this URL:
Krosuri PK, Sekhar R, Srivastava A, Attar A, Shah J. Interim results of a study of the effect of hyperbaric oxygen therapy on healing of chronic leg ulcers. J Mar Med Soc [serial online] 2017 [cited 2020 Jul 12];19:72-3. Available from: http://www.marinemedicalsociety.in/text.asp?2017/19/1/72/213110



Sir,

I would like to share the interim results of my article, the effect of hyperbaric oxygen therapy (HBOT) on healing of chronic leg ulcers. Chronic leg ulcers are a source of major concern for both patients and health-care systems. HBOT is a newer treatment modality being used in treatment of chronic leg ulcers. Treatment involves placing the patient in a compression chamber, increasing the pressure within the chamber to 02 atmospheres absolute (ATA), and administering 100% oxygen for respiration. “But how effective are these? Does HBOT increase rate of healing in people with chronic leg ulcers?” are common research question. Hence, we conducted this study at our center to assess the effectiveness of HBOT on healing of chronic leg ulcers as an adjunct to standard wound care when compared to standard wound care alone.

A prospective, observational, nonrandomized study was planned at our center to assess the effect of HBOT on healing of chronic leg ulcers as an adjunct to standard wound care. This study was planned between February 2016 and December 2017. In this, I would like to highlight the interim results of the ongoing study for the study period between February 2016 and November 2016.

People with chronic leg ulcers coming to our center for wound care were evaluated according to treatment protocol. Information about all patients, who met inclusion and exclusion criteria was collected Informed consent was obtained and they were followed up for 12 weeks in both inpatient and outpatient departments. Arm 1 consisted of patients who received HBOT + standard wound care and Arm 2 consisted of patient who received standard wound care alone. Patients in Arm 1 received 100% oxygen at two ATA for 90 min in a monoplace chamber (HBOT) along with standard wound care. HBOT was given four times a week for 3 weeks at our HBOT unit in a monoplace chamber while continuing standard wound care during HBOT and after therapy. In Arm 2, patients received standard wound care alone. Wound care was standardized throughout the study according to study protocol. Based on the characteristics of the wound, dressings were changed as required (at a minimum of 2 dressing changes per week). Patients were assessed at end of 3rd week, i.e., completion of HBOT and finally at the end of 12th week for change in size of the index ulcer and rate of healing noted. Rate of healing was assessed by reduction in size of index ulcer, i.e., ulcer area covered with epithelial regeneration.[1]

Wound care regimens which included HBOT with similar regimens that excluded HBOT were compared. Accordingly, 11 patients were studied in each arm. Of the 11 patients in ARM 1, one patient had barotrauma and could not complete HBOT, and one patient left the study in between. The mean rate of healing in ARM 1 was 31.6% at end of 3rd week and 62.2% at the end of 12th week. Eleven patients completed standard wound care alone and the mean rate of healing was 14.36% at the end of 3rd week and 34.5% at the end of 12th week.

Based on the Interim results of our study, I would like to conclude that HBOT had an effect on rate of wound healing as an adjunct to standard wound care compared to standard wound care alone. Our findings are somewhat in agreement with studies focused on ulcer healing like The Hyperbaric Oxygen Therapy in Diabetics with Chronic Foot Ulcers (HODFU) study [1] and Krank e et al study.[2] However, more detailed results and analysis will be available on completion of our study.

Acknowledgment

This study is being conducted at Kokilaben Dhirubhai Ambani Hospital and Medical Research Centre. The authors thank Departments of Vascular Surgery and Physical Medicine and Rehabilitation, all the support staff and nurses. This article was presented in abstract form at XXXII Annual conference of Marine Medical Society.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Löndahl M, Katzman P, Nilsson A, Hammarlund C. Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes. Diabetes Care 2010;33:998-1003.  Back to cited text no. 1
    
2.
Kranke P, Bennett MH, Martyn-St James M, Schnabel A, Debus SE, Weibel S. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database of Systematic Reviews 2015;6. Art. No.: CD004123. DOI:10.1002/14651858.CD004123.pub4.  Back to cited text no. 2
    




 

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