• Users Online: 200
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 21  |  Issue : 2  |  Page : 151-157

Hippocampal volume alteration in medication-naive depression patients in comparison to healthy individuals: An Indian perspective


1 Classified Specialist Psychiatry, Department of Psychiatry, 151 Base Hospital, Assam, India
2 Professor, Department of Psychiatry, INHS Asvini, Mumbai, Maharashtra, India
3 Classified Specialist, Pathology, Department of Pathology, 151 Base Hospital, Assam, India

Correspondence Address:
Lt Col (Dr) Barun Kumar Chakrabarty
Classified Specialist, Pathology, Department of Pathology, 151 Base Hospital, Guwahati, Assam
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmms.jmms_19_19

Rights and Permissions

Context: Depression is the most common mental health problem in all the age groups. However, the exact pathophysiology of this devastating disorder remains an enigma. Many hitherto conflicting studies have focused on volumetric measurement of the hippocampus using magnetic resonance imaging (MRI), but few studies have been conducted in our country. Thus, our study envisages comparing hippocampal volumes of medication-naïve depressed individuals against healthy controls. Materials and Methods: This study was conducted both on patients admitted to the hospital and those attending outdoor clinic fulfilling inclusion/exclusion criteria in a tertiary care hospital. The sample consisted of 25 patients freshly diagnosed as Depressive Episode as per the International Classification of Diseases (ICD-10) and 25 healthy controls. Sociodemographic and clinical history pro forma and Hamilton Rating Scale for Depression were administered on all individuals before obtaining the volumetric measurements of the hippocampi of all individuals using a 1.5 Tesla MRI scanner. Results: Our study indicated right hippocampal volumes (RHVs) of depressed individuals were significantly reduced more so with advancing age. It hinted to the lesser effect of severity of depression on RHVs than in the left hippocampal volumes (LHVs). We found that female patients are more predisposed to RHV loss. However, our study did not reveal any significant difference in LHVs or total hippocampal volumes between depressed individuals and healthy controls. Conclusions: It is one of the exclusive studies which have attempted to shed light on the pathophysiology of depression in relation to its severity and hippocampal volumes in the Indian context.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed221    
    Printed0    
    Emailed0    
    PDF Downloaded19    
    Comments [Add]    

Recommend this journal