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ORIGINAL ARTICLE
Year : 2014  |  Volume : 16  |  Issue : 1  |  Page : 38-40

Low serum testosterone levels in patients with breast cancer


1 Resident(Surgery), INHS Asvini, Colaba, Mumbai-05, India
2 Sr.Adv Surgery & Cardiothoracic Surgery, INHS Asvini, Colaba, Mumbai-05, India
3 Sr Adv Surgery & Oncosurgery, INHS Asvini, Colaba, Mumbai-05, India

Correspondence Address:
P A Deshmukh
Sr.Adv Surgery & Cardiothoracic Surgery, INHS Asvini, Colaba, Mumbai-05
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0975-3605.203338

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Background: Correlation between circulating sex steroid levels and breast cancer has been controversial To further elucidate the role of endogenous hormones in breast cancer, we aimed to assess correlation between serum testosterone levels and breast cancer prevalence. Materials & Methods: Levels of serum testosterone by Enzyme Immunoassay (EIA) in 56 patients with histologically verified breast cancer and 55 age-matched control patients. Results: The mean Serum Testosterone level in the control group was 22.58, SD 7.12 (n=55). The mean Serum Testosterone level in the Breast cancer group was 17.69, SD 4.68(n=56). Serum testosterone levels were significantly lower in breast cancer cases vs. controls Conclusions: Serum testosterone levels, are significantly lower in patients with breast cancer compared to age-matched control patients. These findings support the protective role of biovailable testosterone in counteracting the proliferative effects of estrogens on mammary tissue.


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