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Microneedle-assisted steroid delivery therapy in the management of hypertrophic scars: A split-lesion study


1 Consultant Reconstructive Surgery & Ex Additional Director General Medical Services (Navy), IHQ of MoD (Navy), New Delhi, India
2 Department of Dermatology, INHS Asvini, Mumbai, India

Correspondence Address:
Jandhyala Sridhar,
INHS Asvini, Colaba, Mumbai - 400 005, Maharashtra
India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmms.jmms_108_20

Introduction: Microneedle assisted transdermal delivery is an emerging technique of drug delivery on the horizon with exciting potential therapeutic applications. Aims and Objectives: To study the role of microneedling assisted steroid therapy in the management of hypertrophic scars and make suitable recommendations on employability of the procedure as a treatment modality. Materials and Methods: Twenty six consecutive patients with hypertrophic burn scars were studied. Each scar was divided into two halves–control and test. Both halves received topical fluticasone propionate cream 0.05% once daily, silicone gel sheet and a pressure garment. In addition, the test half received microneedling therapy followed by fluticasone propionate cream 0.05% application twice weekly for twelve sittings. The two halves were evaluated for response using the Vancouver Scar Scale (VSS) at the beginning and end of therapy. Results: Twenty patients completed the study. No statistically significant difference was noted in the VSS scores of the two halves. Subjective relief of pruritus was found to be statistically significant in the test half. Conclusion: This study found that percutaneous microneedling assisted steroid therapy as per the the regimen used in this study produced no objectively assessed benefit in the management of hypertrophic scars. Relief of pruritus was noted.


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    -  Vishwanath G
    -  Sridhar J
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