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A study to evaluate reduction in blood loss by topical application of tranexamic acid in burn wound surgery

1 Department of Reconstructive Surgery, INHS Asvini, Colaba, Mumbai, Maharashtra, India
2 Consultant Reconstructive Surgery & Ex Additional Director General Medical Services (Navy), IHQ MoD (Navy), New Delhi, India

Correspondence Address:
Nagamahendran Rajendran,
Resident, Department of General Surgery, INHS Asvini, Colaba, Mumbai, Maharashtra – 400005
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmms.jmms_25_20

Background: Blood loss and problems associated with blood transfusion in burn wound excision is a major challenge a surgeon has to face. Topical application of antifibrinolytics has been used in many surgical fields. This study was conducted to assess the reduction of blood loss in burn wound excision by topical application of tranexamic acid. Materials and Methods: This Prospective observational study was conducted in a tertiary care hospital between February 2018 and May 2019. Results: In this study, we observe that by adding 0.5% tranexamic acid to 1 in 200,000 adrenalin topical solution, blood loss can be reduced while burns excision and skin grafting. In this study, after the application of tranexamic acid, the average blood loss per unit area reduced by 36% with significant P < 0.05. Conclusions: The use of tranexamic acid is effective and safe to use for topical use in concentration of 0.5% for reduction of blood loss in burn wound excision. However, further study with larger study group, should be done to confirm the findings of this study and further authenticating the results.

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