Journal of Marine Medical Society

FRONTIER IN MEDICINE
Year
: 2012  |  Volume : 14  |  Issue : 1  |  Page : 46--48

Neural stem cells and post traumatic epilepsy: The importance of seizure control


KI Mathai1, S Ranjan2, S Das3, A Chagla4 
1 Senior Advisor, Neurosurgery, INHS Asvini, Colaba, Mumbai 400 005, India
2 Senior Advisor, Medical Oncology, INHS Asvini, Colaba, Mumbai 400 005, India
3 Senior Advisor, Paediatric & Haematology, INHS Asvini, Colaba, Mumbai 400 005, India
4 Professor, Dept of Neurosurgery, KEM Hospital, Mumbai, India

Correspondence Address:

Post traumatic seizures induce structural and neurochemical changes in the Neural Stem cell (NSC) niches. The NSC niche shows a classic biphasic response to seizures. In the early weeks after a post traumatic seizure, there is an increase in neurogenesis. However, the integration of these new neurons into existing circuitry is defective leading on to epileptogenic circuits. As seizures continue, there is a decrease in neural proliferation, with consequences on cognition and mood. In this article, we explore the aetiopathogenesis of hippocampal epileptic circuitry and discuss conceptual and evolving therapeutic options.


How to cite this article:
Mathai K I, Ranjan S, Das S, Chagla A. Neural stem cells and post traumatic epilepsy: The importance of seizure control.J Mar Med Soc 2012;14:46-48


How to cite this URL:
Mathai K I, Ranjan S, Das S, Chagla A. Neural stem cells and post traumatic epilepsy: The importance of seizure control. J Mar Med Soc [serial online] 2012 [cited 2021 Sep 24 ];14:46-48
Available from: https://www.marinemedicalsociety.in/article.asp?issn=0975-3605;year=2012;volume=14;issue=1;spage=46;epage=48;aulast=Mathai;type=0